The reason why hsa_circ_0006848 was selected as the object of this study is that in our previous Mass Spectrometric analysis, ribosomal protein L6 (RPL6), which as early detection marker of cancer [12], was found to be significantly downregulated in EGC, and more interestingly, hsa_circ_0006848 may exert an oncogenic role in GC through sponging miR-329-5p targets RPL. Here, RPL6 is linked to cancer.