Multiple regression analysis at sites of BMD and AI of TG/HDL-C ratio in subgroups dividing by sex and obesity after adjustment of age, SBP, glucose, Cre, Hb, smoking, habits of exercise, and vegetarian diet showed major significant positive correlations in all regions at male nonobese subgroup, in bilateral femoral neck and total hip regions at female nonobese subgroup, and in bilateral total hip regions of obese females (Table 5). The gene discussed is GSTM1; the disease is obesity due to melanocortin 4 receptor deficiency.