By integrating the expression profiles of lncRNA and mRNA, several screened lncRNAs including DNAJC3-AS1, WDFY3-AS2, LINC00482, and DLEU2 in the subpathways of PI3K-Akt signaling pathway, focal adhesion, and prostate cancer might play crucial roles in orthodontic forces pathogenesis. This evidence concerns the gene DLEU2 and Familial prostate cancer.