CML was also found to increase RAGE, VEGF, and MCP-1 gene expression in G361 cells in a bell-shaped manner; mRNAs reached peak levels at 4 and 24 hours after treatment with 1 and 0.1 μg/ml CML, respectively (Figures 4(a)–4(f)). This evidence concerns the gene VEGFA and chronic myelogenous leukemia, BCR-ABL1 positive.