RAGE-aptamer at 1 or 10 nM also completely inhibited the upregulation of RAGE, VEGF, and MCP-1 mRNA levels in 0.1 μg/ml CML-exposed G361 cells (Figures 4(g)–4(i)). The gene discussed is CCL2; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.