Since CML stimulates RAGE expression in both cell culture and animal models [5, 24, 25], local injection of RAGE-aptamer may decrease CML, RAGE, and nitrotyrosine expression levels in the G361 tumors by breaking the positive feedback loop among the CML-RAGE-oxidative stress system. This evidence concerns the gene BCR and chronic myelogenous leukemia, BCR-ABL1 positive.