EGFR and non-small cell lung carcinoma: Osimertinib was further investigated in the randomised international Phase 3 AURA3 trial, which compared this compound with platinum–pemetrexed combination chemotherapy in EGFR T790M-positive NSCLC patients following progression during prior EGFR-TKI treatment.10 The median PFS for patients treated with osimertinib was more than twice that of those treated with platinum-based chemotherapy (10.1 versus 4.4 months, hazard ratio [HR]: 0.30; 95% CI: 0.23–0.41, P < 0.001).