Eberlain et al.62 identified NRAS mutations, including the novel E63K mutation, in osimertinib-resistant EGFR-mutant NSCLC cell lines together with a gain of copy number of wt NRAS or wt KRAS in cell populations resistant to gefitinib, afatinib, WZ4002 or osimertinib. Here, EGFR is linked to non-small cell lung carcinoma.