HLA-B and melanoma: Melanomas are immunogenic tumors that typically express high levels of MHC-I; however, melanocytes originate from the neural crest, and selective transcriptional downregulation of HLA-B has been reported in melanoma cell lines (Marincola et al., 1994), while melanoma dedifferentiation with expression of neural crest markers has been linked to acquired immunotherapy resistance (Landsberg et al., 2012, Mehta et al., 2018).