In contrast to the peptide pulsing assay (Figures 4E–4G), pretreatment with EZH2i alone was sufficient to prime mSCLC-OVA cells to induce activation of co-cultured OT-I T cells leading to pro-inflammatory cytokine production (Figure 5C) and effective tumor cell killing over 96 h (Figure 5D), establishing the functional importance of reversing PRC2-mediated repression of the MHC-I APP. The gene discussed is APP; the disease is neoplasm.