Recent studies have shown that inhibition of other epigenetic repressors such as DNA methyltransferases (DNMTs) and KDM1A (LSD1) augment MHC-I expression in cancer cells via derepression of endogenous retroviruses, which activates type I IFN signaling (Chiappinelli et al., 2015, Roulois et al., 2015, Sheng et al., 2018). The gene discussed is KDM1A; the disease is cancer.