Like human neuroendocrine tumors, mouse SCLC (mSCLC) lacked cell surface MHC-I and exhibited low expression of multiple MHC-I APP genes (Figures 4A and S5A), which were induced following genetic disruption or pharmacological inhibition of PRC2 (Figures 4B, 4C, S5B, and S5C). The gene discussed is APP; the disease is small cell lung carcinoma.