Therefore, the purpose of the present study was to investigate the expression of the STIM1 protein in NSCLC vs. normal tissue specimens, and then perform in vitro and nude mouse xenograft experiments to verify the effects of STIM1 on NSCLC cells, aiming to elucidate the role of STIM1 in NSCLC cells. This evidence concerns the gene STIM1 and non-small cell lung carcinoma.