A recent study investigated the role of STIM1 in tumor cell migration and the metastatic cell phenotype; increased expression of STIM1-ORAI1-based SOCE appears to promote breast cancer metastasis due to the stimulation of breast tumor cell migration[36], Furthermore, STIM1 knockdown may inhibit the invasion and migration of A549 lung cancer cells in vitro and in vivo[37]. This evidence concerns the gene ORAI1 and lung cancer.