Clearly, a potential role of inflammation in schizophrenia pathogenesis is not as straightforward as once thought, given that protective effects of high CRP levels have been reported from MR analysis by Hartwig et al.18 and replicated here by Lin et al. 17As noted by Hartwig and colleagues,18 low CRP could perhaps increase schizophrenia risk by increasing the risk of infection. The gene discussed is CRP; the disease is infection.