Our analysis across tumour types has detected LD Wnt alterations in colorectal (10%), stomach (2%), endometrial (1%) and pancreas (1%) tumours while recent work has identified a subset of hepatocellular carcinomas (1%) with RSPO2 gene fusions.24 Detection of these alterations at diagnosis might allow these patients to benefit from chemotherapeutic Wnt ligand suppression. This evidence concerns the gene RSPO2 and hepatocellular carcinoma.