APCDD1 and neoplasm: We identified 26 differentially methylated probes (DMPs) annotated to four of the five differentially expressed Wnt NR genes (AXIN2, NKD1, APCDD1, NOTUM) (online supplementary table 6); 25/26 of these probes were significantly hypermethylated (online supplementary table 6), with significantly elevated mean beta values for each of the four NR genes in LD versus LI tumours (figure 3A, online supplementary figure 4).