Osimertinib provided superior median PFS of 17.2 months compared to 8.5 months for gefitinib or erlotinib in treatment-naïve NSCLC patients, resulting in FDA approval to treat patients with classical EGFR mutations with osimertinib as a first-line therapy in 2018 [31]. The gene discussed is EGFR; the disease is non-small cell lung carcinoma.