The impact of EPCR‐binding IEs on the protein C pathway proposed above is consistent with features of CM pathogenesis, but most studies have found this IE adhesion phenotype to be associated with severe malaria in general, rather than with CM specifically.209, 215, 216, 217, 226, 227 However, this lack of specificity can be explained if CM pathogenesis requires parasites that express PfEMP1 variants that bind both to EPCR and ICAM‐1 (the abovementioned “double binders”). Here, ICAM1 is linked to malaria.