C1QBP and malaria: IEs can also bind to other IEs via platelets (thrombocytes); a phenotype referred to as clumping.167 Clumping has been associated with severe malaria including CM in some, but not all studies.169, 278, 279 The platelet receptor involved appears to be gC1qR/HABP1/p32, and as this receptor is also present on cerebral microvascular endothelium, it provides a plausible link between clumping and C.168 However, to our knowledge it is not known whether IE affinity for gC1qR/HABP1/p32 is mediated by PfEMP1 or whether this adhesion phenotype is significantly involved in the pathogenesis of CM.