VEGFA and retinal disorder: Increased concentration of Ang‐2 with decreased levels of Ang‐1 has been associated with development of severe malaria in several studies,113, 114, 115, 147, 155 and children with retinopathy‐positive CM have higher levels of Ang‐2, Ang‐2/Ang‐1, soluble Tie‐2, von Willebrand Factor, VEGF, and sICAM‐1, and lower levels of Ang‐1, compared to CM patients without retinopathy.114 Both Ang‐1 and Ang‐2 are regulated by nitric oxide (NO) produced in the endothelium from L‐arginine.