This group included well-established (e.g., NT-proBNP) and more recently recognized (e.g., ST2) plasma biomarkers of HF, together with factors recently associated with this disease (e.g., GDF15, IGFBP7, TfR) and one factor that was only just now linked to HF (galectin-4) [13]. The gene discussed is IGFBP7; the disease is hydrops fetalis.