Among the 12 loci, rs11125927 at chr.2 contained TMEM17 gene in the LD block, which is a cilium associated gene reported to suppress invasion and migration of non-small cell lung cancer by restoring Occuludin and Zo-1 expression through inactivation of ERK-P90RSK-Snail pathway27. The gene discussed is RPS6KA1; the disease is non-small cell lung carcinoma.