CXCR2 and cancer: CXCL5 and its only known functional receptor CXCR2 play a role in promoting angiogenesis, migration, invasion, local recruitment of neutrophils, and poor response to chemotherapies54–56,58–60 as well as with cancer progression and metastasis in breast, prostate, liver, bladder, and colorectal cancers54–56,59,60.