MAPK1 and cancer: Furthermore, as compared with control, enforced expression miR-574-5p in GC cells highly enriched several terms reported to improve cancer cell growth, including positive regulation of cell division and cell cycle, ribosomal biogenesis and DNA replication, meanwhile showed dramatic downregulation of the terms involved in tumor suppression, including cell cycle arrest, negative regulation of cell migration, negative regulation of cell proliferation, negative regulation of ERK1 and ERK2 cascade (Fig. 3i).