Regarding the role of RAGE signaling in endothelial dysfunction, studies showed that AGE increased endothelial permeability through the RAGE/Rho signaling pathway or Src phosphorylation in human umbilical vein endothelial cells (HUVECs)14,15 and that AGE-induced Src phosphorylation and barrier dysfunction were inhibited in the pulmonary microvascular endothelial cells of RAGE knockout mice14. The gene discussed is SRC; the disease is endothelial dysfunction.