Moreover, tumor (red) samples had significantly higher TIP-B1 expression when compared to paired normal (black) samples across 26 human tumor types (Figure 1G) from GEPIA webtools, and poorer prognosis in many human cancers, including esophageal carcinoma, head-neck carcinoma, liver carcinoma, pancreatic ductal adenocarcinoma, and rectum adenocarcinoma (Supplementary Figure 3), which further suggested that TIP-B1 might play an oncogenic role in various human cancer types. Here, SH3BGRL3 is linked to rectum adenocarcinoma.