Besides the observation that CCL5 is produced by PDAC cells in the same manner as CCL2 [27], a recent report elegantly showed that the secretion of RANTES and TNF-α through macrophages secrete RANTES/CCL5 and TNF-α in pancreatitis induced acinar-to-ductal metaplasia (ADM). The gene discussed is TNF; the disease is pancreatitis.