NFKB1 and neoplasm: In addition to this direct effect of anti-apoptotic NF-κB target genes on PDAC cell survival, some apoptotic stimuli like TNF are also NF-κB target genes that provide auto- and paracrine death receptor ligand loops either through secretion of the death ligands by tumor cells or by infiltrating immune cells which lead to enhanced proliferation and/or survival [23,24].