LDHA and cancer: Understanding that ALDH activity, which is a marker of cancer stemness, is also implicated in metastasis, therapy failure, and poor prognosis [28], we demonstrated that compared to the parental or vehicle-treated neurospheres, 6 μM LCC-09 suppressed ALDH activity in the D54MG neurospheres by 34.4% or 59.1%, respectively; while in the U87MG neurospheres, it elicited a 30.2% or 42.1% reduction, respectively (Figure 4B).