The above is contextually relevant, especially as aberrant expression of the receptor activator of NF-κB ligand (RANKL) characterizes highly metastatic glioma cells, and the constitutively high expression of RANKL in GBM cells induces the activation of neighboring astrocytic glial cells in the TME through NF-κB signaling [9,13]. The gene discussed is NFKB1; the disease is glioblastoma.