The above is contextually relevant, especially as aberrant expression of the receptor activator of NF-κB ligand (RANKL) characterizes highly metastatic glioma cells, and the constitutively high expression of RANKL in GBM cells induces the activation of neighboring astrocytic glial cells in the TME through NF-κB signaling [9,13]. Here, TNFSF11 is linked to central nervous system cancer.