A KEGG “endometrial cancer” pathway and pathways related to endometrial cancer risk factors, such as obesity (e.g., “signaling by leptin”), insulinemia (e.g., “insulin receptor signalling cascade”) and estrogen exposure (e.g.,“plasma membrane estrogen receptor signalling”) were also found among the significantly enriched pathways. This evidence concerns the gene ESR1 and obesity due to melanocortin 4 receptor deficiency.