A KEGG “endometrial cancer” pathway and pathways related to endometrial cancer risk factors, such as obesity (e.g., “signaling by leptin”), insulinemia (e.g., “insulin receptor signalling cascade”) and estrogen exposure (e.g.,“plasma membrane estrogen receptor signalling”) were also found among the significantly enriched pathways. Here, LEP is linked to obesity due to melanocortin 4 receptor deficiency.