PRPF8 and prolactin-producing pituitary gland adenoma: PRLomas also exhibited a clearly dysregulated expression pattern of spliceosomal components (12 out of 42) compared to NPs (Figure 4A and Figure S6), with a clear overexpression of three major spliceosome components (PRPF40A, PRPF8, and RBM22), a downregulation of one minor spliceosome component (RNU11), and an overexpression of eight SFs (MAGOH, SRRM4, PTBP1, RAVER1, RBM3, KHDRSB1, SRSF2, and SRSF6) (Figure 4A and Figure S6).