KHDRBS1 and ACTH-producing pituitary gland adenoma: Conversely, PLS-DA analysis showed a clear separation between ACTHomas and NPs (Figure 3C), and the VIP score of PLS-DA analysis revealed that the pattern of two SFs with the highest score (MAGOH and KHDRBS1) was able to discriminate between ACTHomas and NPs (Figure 3D).