RNU1-1 and neoplasm: Together with the identification of clearly distinct, tumor type–dependent dysregulations of the components of the splicing machinery, it is worth noting that we also pinpointed a common pattern of dysregulation of two minor spliceosome components (RNU11 and RNU6ATAC) and two SFs (SRSF1 and SRRM4) in most PitNETs, irrespective of their subtype, an observation that might be patho-physiologically relevant and thus bear future clinical potential.