PRLomas also exhibited a clearly dysregulated expression pattern of spliceosomal components (12 out of 42) compared to NPs (Figure 4A and Figure S6), with a clear overexpression of three major spliceosome components (PRPF40A, PRPF8, and RBM22), a downregulation of one minor spliceosome component (RNU11), and an overexpression of eight SFs (MAGOH, SRRM4, PTBP1, RAVER1, RBM3, KHDRSB1, SRSF2, and SRSF6) (Figure 4A and Figure S6). Here, RBM22 is linked to prolactin-producing pituitary gland adenoma.