To evaluate the functional effects of chemerin in adrenocortical carcinoma, Li-Chittenden et al. performed a series of in vitro studies comparing the effects of transient human chemerin overexpression in H295R and SW13 adrenocortical carcinoma or HEK293 human embryonic kidney cells to exogenous chemerin treatment [79]. The gene discussed is RARRES2; the disease is adrenal cortex carcinoma.