This leads to reduced production and secretion of the pro-tumorigenic factors, granulocyte-macrophage colony-stimulating factor (GM-CSF) from tumor cells and IL-6 from hepatocytes, which in turn suppress the numbers of tumor-infiltrating MDSCs and allows for a restoration of T-cell immunity and reduced angiogenesis in the tumor microenvironment [92]. This evidence concerns the gene IL6 and neoplasm.