IHC of BRD4 in age-matched human nondiabetic, autoantibody-positive (positive for serum beta cell autoantibody, but not diabetic) and T1D donor pancreas sections showed that it was expressed in the vast majority of INS+ and INS− islet cells and acinar cells in each donor (Figure 3a), similar to the staining in 8-week-old NOD mice (Figure 1b). This evidence concerns the gene BRD4 and type 1 diabetes mellitus.