NFE2L2 and injury: The role of Nrf2 in mediating the anti-inflammatory and antiapoptotic efficacies of FN in MTX-administered rats was supported by previous reports which demonstrated increased expression of Nrf2 and suppressed inflammation in acetaminophen-induced hepatotoxicity [24], traumatic brain injury [64], and rhabdomyolysis-induced renal injury [48] in rodents.