Using magnetic resonance spectroscopy, we previously observed that mild systemic inflammation, induced with the low 100 μg/kg dose of LPS, rapidly altered hippocampal metabolism in the APPswe/PS1dE9 (APP/PS1) mouse model of amyloidosis and its wild-type (WT) littermates at early to advanced pathological stages (Pardon et al., 2016). Here, APP is linked to amyloidosis.