APP and amyloidosis: Thus, the fact that we did not find differences in microglial number and morphology between sexes and genotypes is consistent with the lack of microglial response at 4 h post-LPS, and published reports showing that changes in microglial phenotypes, occurring with the progression of amyloidosis in this APP/PS1 model, manifest after the age of 5 months (Martin et al., 2017).