APP and amyloidosis: In the same APP/PS1 mouse model of amyloidosis used in our previous study, age- and region-specific metabolic perturbations have been reported in the brain of males and females, but sex differences have not been systematically tested (Gonzalez-Dominguez et al., 2014, Maroof et al., 2014), although they have been seen with brain aging in WT mice and are thought to contribute to differential susceptibility to AD-like pathology (Zhao et al., 2016).