No major differences in the response to LPS were seen here between WT and APP/PS1 mice, which can be due to the early pathological stages under investigation, since differences in microglial activation are subtle before the age of 4 months (Martin et al., 2017, Ruan et al., 2009), and/or the early time point, as the resolution of neuroinflammation is an active process particularly impaired in neurodegenerative diseases (Schwartz and Baruch, 2014). This evidence concerns the gene APP and neurodegenerative disease.