CD1D and chronic myelogenous leukemia, BCR-ABL1 positive: In chronic myeloid leukemia, activation of the Rho‐associated protein kinase (ROCK) mediates the reduction of membrane expression of CD1d but not the reduction of intracytoplasmatic levels or mRNA transcripts34 and a certain kind of invasive breast cancer is also associated with downregulated CD1d.35 Regarding the CD1d receptor molecule, a Thr/Ser residue motif in the cytoplasmatic tail seems to be pivotal for the surface expression.36 Nevertheless, future research has to focus on the mechanism of CD1d downregulation, especially in ATCs.