TLR9 and systemic lupus erythematosus: Virus infection inhibits NKT cell‐CD1d function among others through downregulation of CD1d.30, 31 In this context, herpes simplex virus 1 phosphorylates the type II kinesin motor protein KIF3A which lead to the suppression of CD1d.32 Otherwise, in systemic lupus erythematosus TLR9‐induced microRNA‐155 and Ets‐1 decrease membrane CD1d levels.33 But also in malignancies CD1d degradation could be observed.