In chronic myeloid leukemia, activation of the Rho‐associated protein kinase (ROCK) mediates the reduction of membrane expression of CD1d but not the reduction of intracytoplasmatic levels or mRNA transcripts34 and a certain kind of invasive breast cancer is also associated with downregulated CD1d.35 Regarding the CD1d receptor molecule, a Thr/Ser residue motif in the cytoplasmatic tail seems to be pivotal for the surface expression.36 Nevertheless, future research has to focus on the mechanism of CD1d downregulation, especially in ATCs. This evidence concerns the gene CD1D and invasive breast carcinoma.