To determine if the Zpbp2 region was involved in regulation of Ormdl3 or Nr1d1 expression in mice, we used a mouse strain that lacks Zpbp2 and focused on lungs, small intestine (ileum) and liver, the three organs that are affected in human diseases with association to the ZPBP2-ORMDL3 region, i.e. asthma, IBD and PBC. This evidence concerns the gene ORMDL3 and primary biliary cholangitis.