Our previous study demonstrated that the expression of the immune inhibitory gene FcγRIIB was a risk factor for poor survival and correlated with the immunosuppressive microenvironment in high-grade gliomas[13].We thus analyzed the association of FcγRIIB expression with the mesenchymal signature and IGFBP2 expression in gliomas. The gene discussed is IGFBP2; the disease is central nervous system cancer.