As the serum protein level of IGFBP2 was significantly increased in the orthotopic GL261 tumor bearing mice compared to the no tumor mice (S1A Fig, ** p < 0.01), we treated the mice with anti-IGFBP2 intraperitoneally after 7 days injection of tumor cells until the complete death of the control mice. The gene discussed is IGFBP2; the disease is neoplasm.