Recently, we have reported that IGFBP2 was overexpressed in the four GBM molecular subtypes (classical, neural, proneural, and mesenchymal subtypes), but its upregulated expression of cell proliferation genes found in neural stem cells was extremely correlated with its overexpression only in non-mesenchymal GBM cells, but not in mesenchymal ones[33]. The gene discussed is IGFBP2; the disease is glioblastoma.