PROS1 and type 2 diabetes mellitus: Some studies have evaluated the levels of some coagulation parameters in T2DM and have reported reduced plasma levels of anti-thrombotic markers [8, 13, 14] and elevated levels of pro-thrombotic markers [15–18] with Erem et al. reporting an inverse association between glycated haemoglobin (HbA1c) and plasma protein S levels [18].