Interestingly, we found the MRS to be a strong marker for insulin sensitivity (even though they independently contribute to weight gain prediction) and showed that individuals with higher MRS have lower risk of developing T2D in one cohort, indicating that it may be more clinically important to track individuals with lower MRS who are less likely to gain weight but more metabolically unhealthy with respect to T2D. Here, INS is linked to type 2 diabetes mellitus.