IL37 and colitis: However, increasing evidence shows that inflammation plays a critical role in OA pathology, suggesting that targeting inflammation in OA could be a promising strategy.6, 7 IL‐37 has emerged as a fundamental inhibitor of the innate immune response, attenuating inflammation in models of periodontal inflammation,32 gout33 and colitis.34 However, no study has investigated the effect of IL‐37 on TMJ inflammation.