Of note, while SOX2 is supposed to bind the 3′ untranslated portion of WWC1 mRNA in osteosarcoma,23 multiple SOX2 binding peaks are identified in the upper region of WWC1 in ESCC TT cells, suggesting SOX2 can regulate the Hippo‐YAP1 signaling in a context‐dependent manner. Here, YAP1 is linked to esophageal squamous cell carcinoma.