To understand the transcriptional regulation involved in the YAP1 activation in ESCC, we first assessed chromatin immunoprecipitation/high‐throughput sequencing (ChIP‐seq) data of endogenous SOX2 and p63 in ESCC cell line TT, then integrated with RNA‐seq data from human ESCC in the TCGA dataset (Figure 2). The gene discussed is SOX2; the disease is esophageal squamous cell carcinoma.