Recent evidence suggests that SOX2 and ACTL6A/p63 may regulate Hippo pathway components in osteosarcoma and HNSCC, respectively.14, 23 In this report, we show that SOX2, ACTL6A, and TP63 are co‐amplified and upregulated in ESCC samples. The gene discussed is TP63; the disease is head and neck squamous cell carcinoma.