Recent evidence suggests that SOX2 and ACTL6A/p63 may regulate Hippo pathway components in osteosarcoma and HNSCC, respectively.14, 23 In this report, we show that SOX2, ACTL6A, and TP63 are co‐amplified and upregulated in ESCC samples. This evidence concerns the gene ACTL6A and head and neck squamous cell carcinoma.