Overexpression of the repressed WWC1 by a plasmid27 in Eca109‐SOX2 cells potently abrogated the SOX2‐induced migration and invasion (Figure 5H,I), providing evidence that repression of WWC1 is required for the functionality of SOX2 in ESCC. The gene discussed is SOX2; the disease is esophageal squamous cell carcinoma.