TP63 and esophageal squamous cell carcinoma: To understand the transcriptional regulation involved in the YAP1 activation in ESCC, we first assessed chromatin immunoprecipitation/high‐throughput sequencing (ChIP‐seq) data of endogenous SOX2 and p63 in ESCC cell line TT, then integrated with RNA‐seq data from human ESCC in the TCGA dataset (Figure 2).