PROX1 and colorectal carcinoma: PROX1 was recently shown to suppress MMP14 expression in breast cancer, as well as hepatocellular and colorectal carcinoma; here we showed that survival is worse specifically among those gastric cancer patients with a high MMP14 and a low PROX1 expression.21 To further explore the connection between MMP14 and PROX1 in gastric cancer, we proceeded by studying the expression levels in cell lines.