Few studies of PROX1 in gastric cancer have been published, reporting inconsistent results, showing that it is highly expressed in cancer compared to healthy tissue and associates with a worse although paradoxically with a better patient prognosis.17, 18, 19, 20 On the one hand, Ueta et al20 concluded that nuclear PROX1 expression associates with a worse prognosis. The gene discussed is PROX1; the disease is cancer.