The results indicated that high expression of G3BP1 was proved to be a poor prognostic factor for NSCLC patients (P = .039), as well as pathological degree (P = .002) and clinical stage (P = .036). Nevertheless, increased expression of p‐AKT and YB1 had no significant impact on prognosis of NSCLC patients. Here, G3BP1 is linked to non-small cell lung carcinoma.