It has been reported that YB‐1 could bind to the 5’UTR of G3BP1 transcripts to up‐regulate translation, thus controlling the validity of the G3BP1 SG nucleator in SG assembly and promoting the tumor progression, which might explain the positive correlation between G3BP1 and YB1, and indicated they may promote the occurrence and development of NSCLC together. The gene discussed is YBX1; the disease is neoplasm.