In addition, it was found that PTEN could down‐regulate the expression of G3BP by inhibiting PI3K/AKT signaling pathway in normal cells and there was a negative correlation between the expression of PTEN and G3BP.27 In this work, we showed G3BP1 was highly overexpressed in NSCLC tissues including lung ADC and SCC, compared with noncancerous lung tissues, which was consistent with the above findings and we further confirmed that it had an evidently positive relation with clinical stage of NSCLC patients. Here, G3BP1 is linked to AIDS dementia complex.