G3BP1 and breast cancer: Besides, it was reported that G3BP1 promoted the metastasis of hepatocellular carcinoma through upregulation of Slug expression and might be a new predictor for prognosis.24 Also, G3BP1 was proved to be positively related to tumor classification, tumor size, lymph node metastasis, and TNM stage and reduced overall survival in gastric cancer patients.25 Intriguingly, Barnes et al26 found that overexpression of G3BP1 protein in breast cancer might be involved in the HER2 signaling pathway.