YBX1 and cancer: It mainly exists in the cytoplasm and acts as a pivotal molecule in activating PI3K/AKT signaling pathway.11 Phosphorylated protein kinase B (p‐AKT) can regulate many proteins related to cell metabolism, apoptosis, proliferation and differentiation, thus inhibiting cell apoptosis and promoting the growth of cancer cells.12 It was reported that YB‐1 could bind to the 5′UTR of G3BP1 transcripts to up‐regulate translation of G3BP1, thus controlling the validity of the G3BP1 SG nucleator in SG assembly and promoting the tumor progression.13