It has been shown that knockdown of G3BP1 downregulated the expression level of p‐PI3K (Tyr458) and p‐AKT (Ser473) in esophageal cancer cells,42 which supports our hypothesis that G3BP1 has a potential role in regulating PI3K/AKT singling pathway. The gene discussed is G3BP1; the disease is esophageal cancer.