SPOP and posterior cortical atrophy: In contrast, PCa‐associated SPOP hotspot mutations such as F133V and W131R confer resistance to BET inhibitors due to upregulation of BET proteins and aberrant occupancy of BRD4 in the genome (Dai et al, 2017; Zhang et al, 2017), implying that specific strategies are needed to effectively treat patients with SPOP‐mutated PCa.