Tool compound small molecule CBP/p300 bromodomain inhibitors have demonstrated an important role for this domain in the coactivator functions of CBP/p300 and significant dose‐dependent inhibition of AR signaling and PCa proliferation in vitro and in vivo (Comuzzi et al, 2004; Heemers et al, 2007; Lasko et al, 2017; Xiang et al, 2018). Here, AR is linked to posterior cortical atrophy.