IRF2BP2 and metastatic malignant neoplasm in the lymph nodes: IRF2BP2 was primarily localized to the nucleus, which is consistent with studies suggesting the multiple functions of IRF2BP2 in the nucleus.2, 3, 4, 5, 6, 7, 8, 9 In addition, IRF2BP2 levels were positively and significantly correlated with tumour size, clinical stage, depth of invasion and lymph node metastasis.