The bioinformatic analysis of the TCGA database indicated that IRF2BP2 was amplified in most types of tumours, including GC (http://www.cbioportal.org/) (Figure 1A), and the level of IRF2BP2 mRNA in primary GC tissues was significantly higher than that in normal tissues (http://ualcan.path.uab.edu/cgi-bin/TCGAExResultNew2.pl?genenam=IRF2BP2&ctype=STAD) (Figure 1B). This evidence concerns the gene IRF2BP2 and neoplasm.