It is of interest that a recent study demonstrated that VGLL4 bound to and stabilized IRF2BP2, leading to increased PD‐L1 expression and immune evasion through IRF2 inhibition.23 However, the IRF2BP2 sequence is highly conserved although in IRF‐2 protein‐deficient organisms, it implies the IRF2‐independent functions of IRF2BP2.8 The present results suggest that the binding of VGLL4 to IRF2BP2 may have an IRF‐2–independent function mediated by YAP1 in GC. This evidence concerns the gene IRF2BP2 and gastric cancer.