In addition, migration and invasion are basic characteristics of malignant tumours40, 41 and the main cause of death in patients with GC, and a growing body of evidence indicates that tumour cells have high motility and invasiveness after EMT, in which E‐cadherin and vimentin are considered the most critical molecules.42 In the present study, knocking down IRF2BP2 inhibited the migration and invasion of GC cells and EMT. The gene discussed is CDH1; the disease is neoplasm.