YAP1 accumulates in the nucleus, where it binds primarily to DNA‐binding transcription factors TEA domain family members 1‐4 (TEAD1‐4) and transcriptionally coactivates CTGF, contributing to tumorigenesis and cancer progression.20, 21 VGLL4 serves as a transcriptional corepressor in the nucleus by binding to TEAD4 and blocking transcriptional coactivation; moreover, VGLL4 competes with YAP1 for binding to TEAD4.21, 22. The gene discussed is TEAD4; the disease is cancer.