Our previous study indicated that STAT3/SOCS3 signalling pathway played an important regulatory role in the progression of ALI.3 To investigate whether Res suppresses ALI through STAT3/SOCS3 signalling, we compared the therapeutic effects of Res in WT and cKO mice, in which SOCS3 was myeloid cell‐restricted depleted. The gene discussed is STAT3; the disease is acute respiratory distress syndrome.