In the LPS‐induced murine ALI model, Res can effectively attenuate the severity of ALI, and the beneficial effects are associated with lower NLRP3 inflammasome activation and release of IL‐1beta and IL‐18.11 However, whether Res suppresses ALI through modulation of macrophage subtypes and whether STAT3/SOCS3 signalling is involved in the therapeutic effects remains unknown. Here, SOCS3 is linked to acute respiratory distress syndrome.