Loss of function of the C9orf72 gene in murine models recapitulates human autoimmune disease with severe autoimmune phenotypes, high mortality rate, and increased levels of inflammatory cytokines, such as IFN-γ, IL-17A, IL-12p, IL-10, IL-1β, and MCP-1, as well as alterations in hemoglobin levels and peripheral blood cell counts (leukocytes and thrombocytes). The gene discussed is C9orf72; the disease is autoimmune disease.