Furthermore, the phosphorylation levels of STAT3 and NF‐κB p65 were enhanced in GM‐Exo‐treated colon cancer cells, but the levels of p‐STAT3 and p‐p65 were decreased in GM‐Exo subjected to S100A9 knockdown (Figure 4G). This evidence concerns the gene NFKB1 and malignant colon neoplasm.