STAT3 and cancer: MDSCs enhance the stemness of ovarian cancer cells by triggering microRNA101 expression in cancer cells and subsequently repress the corepressor gene C‐terminal binding protein‐2 (CtBP2).13 MDSCs endow stem‐like qualities to breast cancer cells through IL‐6/STAT3 and NO/NOTCH signaling.14 However, the effect of MDSC on CRC cells stemness is unclear.