Since VIP contributes to important physiological functions including anion secretion, the regulation of permeability of epithelial tight junctions, mucosal inflammation, glycemic control, Th1–Th2 balance, and tumor growth, VIP has been suggested to be a therapeutic target for diseases such as diarrhea58, IBD95, diabetes28, autoimmune diseases115, neurodegenerative disorders116, lung disease117,118, sarcoidosis119, and cancers114. The gene discussed is VIP; the disease is neoplasm.