HSD11B1 and obesity due to melanocortin 4 receptor deficiency: Therefore, we hypothesize that the interaction between HSD11B1 rs45487298:delA>insA and H6PD rs6688832:G>A polymorphisms may generate a significant decrease in HSD11B1 levels in adipocytes and other tissues; and consequently, this may decrease the risk of obesity in individuals with T2DM who carry at least three minor alleles of these polymorphisms.