As expected, the frequency of obesity was lower among individuals carrying at least three minor alleles of HSD11B1 rs45487298:delA>insA and H6PD rs6688832:G>A polymorphisms than in the group of individuals with fewer than three minor alleles (24.4% vs. 41.6%, respectively; P = 0.033). This evidence concerns the gene HSD11B1 and obesity due to melanocortin 4 receptor deficiency.