Compared to placebo, CBD significantly decreased subjective anxiety and reduced ethyl cysteinate dimer (ECD) uptake in the left parahippocampal gyrus, hippocampus, and inferior temporal gyrus while increased ECD uptake in the right posterior cingulate gyrus, thus suggesting an antianxiety effect of CBD in SAD probably related to its activity in limbic and paralimbic brain areas [38] (Table 2). The gene discussed is OPN1MW; the disease is Anxiety.