Recently, several surrogate markers of systemic inflammation such as serum C-reactive protein, neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) have been found to be associated with various kinds of cancers including non-small-cell lung cancer, pancreatic adenocarcinoma, gastric cancer, over carcinoma, renal cell carcinoma, colorectal cancers, and endometrial cancers [3–7]. The gene discussed is CRP; the disease is colorectal cancer.