Our study shows that high-nuclear RXRG was associated with ER-positive tumours, and is consistent with previous reports, which shows it confers a better prognostic impact.46 Indeed, the positive correlation between RXRG and ER expression, and association of higher RXRG with improved patient outcome independent of ER expression, suggest that RXRG could be a potential surrogate marker for ER expression in our cohort. The gene discussed is RXRG; the disease is neoplasm.