Moreover, elevated expression of RXRG was associated with ER associated markers, such as GATA3,48 FOXA1,49 BEX,30 STAT343 and MED7.33 As noted earlier, RXRs and RARs form heterodimeric complexes, which bind DNA at specific retinoid responsive elements and regulate the various transcriptional processes.12 In breast cancer, functional interactions between retinoic acid and oestrogen signalling are complex and well documented.2,19,20. This evidence concerns the gene BEX3 and breast cancer.