Elevated N-cadherin expression is associated with epithelial–mesenchymal transition (EMT) and tumour aggressiveness.55 In thyroid carcinoma, administration of ligands selective for RXRG resulted in a 30% reduction in cell proliferation,56 which is in agreement with low proliferation index and high RXRG expression. This evidence concerns the gene CDH2 and thyroid gland carcinoma.