ITGAM and neoplasm: Interestingly, additional analysis of the CD11b+Gr1+ infiltrating cells demonstrated that while in the AT3 tumours injected in Nlrp3−/− mice depletion of inflammasome in CAFs resulted in reduced infiltration of the monocytic fraction of CD11b+Gr1+ cells, depletion of Il1b or Nlrp3 in CAFs in Met-1 tumours injected to WT mice attenuated recruitment of the granulocytic (CD11b+Ly6G+Ly6Clow) fraction of CD11b+Gr1+ cells (Fig. 4m, n).