Interestingly, while in the primary tumour knockout of CAF-derived IL-1β resulted in attenuated recruitment of the granulocytic fraction (CD11b+Ly6G+Ly6Clow), in the metastatic microenvironment CAF-derived IL-1β was important for the recruitment of the monocytic fraction (CD11b+Ly6ChighLy6G−) (Fig. 5i–l, Supplementary Fig. 6c–k). The gene discussed is IL1B; the disease is neoplasm.