Additionally, immunohistochemistry (IHC) of advanced mammary carcinoma tissue sections from MMTV-PyMT mice confirmed that in addition to its activation in tumour cells, NLRP3 is upregulated in CAFs, but not in normal mammary fibroblasts (NMFs) (Fig. 1g, h, Supplementary Fig. 2a). The gene discussed is NLRP3; the disease is breast carcinoma.