Remarkably, we found that multiple genes that belong to the NLRP3 inflammasome pathway, including P2rx7, Nlrp3, Casp1, Il1a and Il1b are upregulated in CAFs isolated from mammary carcinoma, but not in normal mammary tissue, or in fibroblasts isolated from mammary hyperplasia (Fig. 1d, e). Here, CASP1 is linked to breast carcinoma.