To identify downstream effectors of HMGB1-TLR2 mediated cancer cell dedifferentiation, we examined the expression levels of several key signaling pathways regulating cancer cell plasticity, and noticed the protein expression of YAP and MOB1 (core component of the Hippo pathway) was slightly enhanced upon rhHMGB1 stimulation (Fig. 4a). Here, TLR2 is linked to cancer.