NOX1 and cancer: Although the presence of low levels of NOX1 in normal cells that do not undergo apoptosis when treated with UM0112176 could argue against NOX1 conferring cancer cell selectivity during UM0112176 treatment, it was shown that low glucose culture media (5 mM) prevented the NOX4 isoform from targeting to lipid rafts in adipocytes retaining it in a low activity membrane fraction55.