PFKFB3 and cancer: To further address whether UM0112176-induced changes can be reproduced by inhibition of glycolysis in cancer cells, we tested the impact of other glycolytic enzymes effectors: alizarin Red S which inhibits phosphoglycerate mutase (PGAM)18 and 3-PO ((2E)-3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one) which indirectly blocks the action of 6-phosphofructo-2-kinase/fructose-bisphosphatase-2 (PFK-2)19.