The expression levels of SEPT9 and paxillin were significantly increased in the lymph node metastasis group compared to the non-lymph node metastasis group (Fig. 1), and SEPT9 expression was positively correlated with lymph node metastasis (γ = 0.367, P = 0.006). The gene discussed is PXN; the disease is metastatic malignant neoplasm in the lymph nodes.