Analysis of Parkin copy-number variation (CNV) by using the liver hepatocellular carcinoma (LIHC) dataset from The Cancer Genome Atlas (TCGA) showed that the Parkin locus was deleted in 38.4% HCC samples and that Parkin expression was significantly associated with Parkin CNV (Fig. S2a, b). This evidence concerns the gene PRKN and hepatocellular carcinoma.