Four different mutations of the R1882 residue in Nav1.2 have been reported as being putatively pathogenic in epilepsy cases (R1882L, R1882P, R1882G, and R1882Q; Carvill et al., 2013; Baasch et al., 2014; Howell et al., 2015; Schwarz et al., 2016; Trump et al., 2016; Parrini et al., 2017; Wolff et al., 2017). The gene discussed is SCN2A; the disease is epilepsy.