Resurgent currents are also enhanced by pro-excitatory disease mutations in other voltage-gated sodium channel isoforms which are associated with pain, myotonia congenital, long-QT syndrome, and SCN8A epilepsies (Jarecki et al., 2010; Patel et al., 2016; Xiao et al., 2019). This evidence concerns the gene SCN8A and epilepsy.