SCN2A and epilepsy: Among the Nav1.2 mutations suspected to cause epilepsy in human patients with otherwise idiopathic epileptic encephalopathies, R1882Q and R853Q are two of the most commonly reported mutations (Carvill et al., 2013; Epi4k Consortium, 2013; Nakamura et al., 2013; Howell et al., 2015; Samanta and Ramakrishnaiah, 2015; Kobayashi et al., 2016; Li et al., 2016; Trump et al., 2016; Wolff et al., 2017).